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Therapy management with sunitinib in patients with metastatic renal cell carcinoma: key concepts and the impact of clinical biomarkers.
- Source :
-
Cancer treatment reviews [Cancer Treat Rev] 2013 May; Vol. 39 (3), pp. 230-40. Date of Electronic Publication: 2012 May 28. - Publication Year :
- 2013
-
Abstract
- Targeted agents have improved prognosis for patients with metastatic renal cell carcinoma (mRCC), and they are changing therapeutic expectations with respect to long-term clinical outcomes for these patients. However, in order to obtain the maximum clinical benefit from targeted agents, effective therapy management is essential and includes optimization of dosing and treatment duration, as well as adequate side-effect management. Sunitinib has demonstrated efficacy for the treatment of patients with mRCC and is a reference standard of care for first-line therapy. However, in clinical practice, it is difficult to determine the best treatment strategy with targeted agents due to long-term tolerability and the development of resistance. An individualized therapeutic strategy in RCC requires a comprehensive understanding of the biology of response and resistance to targeted therapy. Here we review the clinical data regarding the efficacy and safety for sunitinib and highlight the importance of therapy management, as well as the potential use of clinical biomarkers in order to maximize the clinical benefit from sunitinib treatment in patients with mRCC.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antineoplastic Agents adverse effects
Biomarkers, Tumor analysis
Carcinoma, Renal Cell pathology
Humans
Indoles adverse effects
Kidney Neoplasms pathology
Molecular Targeted Therapy
Neoplasm Metastasis
Prognosis
Pyrroles adverse effects
Sunitinib
Antineoplastic Agents administration & dosage
Biomarkers, Tumor metabolism
Carcinoma, Renal Cell drug therapy
Carcinoma, Renal Cell metabolism
Indoles administration & dosage
Kidney Neoplasms drug therapy
Kidney Neoplasms metabolism
Pyrroles administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1967
- Volume :
- 39
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cancer treatment reviews
- Publication Type :
- Academic Journal
- Accession number :
- 22647546
- Full Text :
- https://doi.org/10.1016/j.ctrv.2012.04.009