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[Diet and water-salt balance in rats].
- Source :
-
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova [Ross Fiziol Zh Im I M Sechenova] 2012 Mar; Vol. 98 (3), pp. 363-72. - Publication Year :
- 2012
-
Abstract
- We compared parameters of water-salt balance in Wistar female rats fed normal chows during more than 2 weeks. Potassium content was 1.4-fold higher in diet I than in diet II, and sodium end water content was 3.3- and 7.5-fold higher in diet II than in diet I. Blood osmolality and concentration of Na+, K+, Mg2+ were equal in rats fed different chow. In water-loaded rats (5 ml of water/100 bw per os) fed different chow, urine flow rate did not differ, but solute-free water excretion was higher by 40.2% in the rats fed diet II vs. diet I. The sort of diet did not affect the renal sodium excretion during oral administration of 5 ml 0.9% NaCl per 100 g bw to rats. After vasopressin injection solute-free water reabsorption was 1.5-fold higher in rats fed diet II. Natriuretic and hydruretic effect of exenatide, glucagon-like peptide 1 mimetic, was weaker in rats fed diet I. The data obtained indicate that organism can effectively maintain blood parameters. The modulation of hormone regulatory effects on water and sodium balance was found to depend on the state of organism under diet consumed continuously.
- Subjects :
- Animals
Arginine Vasopressin pharmacology
Blood Pressure drug effects
Diet
Female
Glucagon-Like Peptide 1 administration & dosage
Hormones metabolism
Kidney drug effects
Magnesium metabolism
Potassium urine
Rats
Rats, Wistar
Sodium urine
Sodium Chloride administration & dosage
Osmolar Concentration
Potassium blood
Sodium blood
Water metabolism
Water-Electrolyte Balance
Subjects
Details
- Language :
- Russian
- ISSN :
- 0869-8139
- Volume :
- 98
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
- Publication Type :
- Academic Journal
- Accession number :
- 22645945