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Daphmacromines A-J, alkaloids from Daphniphyllum macropodum.
- Source :
-
Journal of natural products [J Nat Prod] 2012 Jun 22; Vol. 75 (6), pp. 1076-82. Date of Electronic Publication: 2012 May 29. - Publication Year :
- 2012
-
Abstract
- Ten new yuzurine-type Daphniphyllum alkaloids, daphmacromines A-J (1-10), along with seven known alkaloids were isolated from the leaves and stems of Daphniphyllum macropodum. Their structures were elucidated by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry, and the structure of 1 was confirmed by single-crystal X-ray diffraction. The pesticidal and cytotoxic activities of the isolated alkaloids were evaluated in vitro against brine shrimp (Artemia salina) and five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480), respectively. This study also suggested structural revisions of oxodaphnigracine, oxodaphnigraciline, and epioxodaphnigraciline.
- Subjects :
- Alkaloids chemistry
Animals
Antineoplastic Agents, Phytogenic chemistry
Artemia drug effects
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal chemistry
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Leaves chemistry
Plant Stems chemistry
Alkaloids isolation & purification
Alkaloids pharmacology
Antineoplastic Agents, Phytogenic isolation & purification
Antineoplastic Agents, Phytogenic pharmacology
Drugs, Chinese Herbal isolation & purification
Drugs, Chinese Herbal pharmacology
Saxifragaceae chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 75
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 22642560
- Full Text :
- https://doi.org/10.1021/np200960z