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One-year outcomes of consecutive patients treated by Endeavor zotarolimus and Resolute zotarolimus stents: the impact of polymer coating in drug-eluting stent technology.
- Source :
-
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions [Catheter Cardiovasc Interv] 2013 Feb; Vol. 81 (2), pp. 268-73. Date of Electronic Publication: 2012 Nov 14. - Publication Year :
- 2013
-
Abstract
- Background: Polymer-coating represents a key component of drug-eluting stent (DES) technology and its possible impact on vessel-wall healing is a matter of debate. The clinical impact of different polymer-coating may be assessed by comparing the outcome of patients treated by DES having the same stent platform and drug, and differing in the polymer. Thus, we compared the clinical outcome of patients treated by Endeavor Zotarolimus-eluting stent (E-ZES) and Resolute Zotarolimus-eluting stent (R-ZES) as they differ in the polymer-coating only.<br />Methods: At our Institution, E-ZES was available during a first period and then it was substituted by the R-ZES during a second period. Clinical, angiographic, and procedural data were prospectively collected. Clinical follow-up was prospectively obtained up to 1-year. Primary endpoint was the occurrence of major adverse cardiac events (MACE) at 12-month.<br />Results: A total of 467 patients undergoing percutaneous coronary intervention were enrolled: 233 patients treated with E-ZES and 234 with R-ZES. Patients treated by R-ZES had similar clinical characteristics and worse angiographic characteristics compared with those treated by E-ZES. At 12-month follow-up, MACE rate was significantly lower in the R-ZES group compared with E-ZES group (4.2% vs. 14.6%; P < 0.01). This difference was due to nonsignificantly lower rates of death and myocardial infarction and to significant lower rate of target-lesion-revascularization (R-ZES 3.4% vs. E-ZES 10.3%, P < 0.01).<br />Conclusions: The results of this study suggest that the clinical outcome of patients treated by DES differing for the polymer coating only may be different. Polymer coating is a pivotal, probably underrated, component of DES technology which may influence the clinical performance of DES.<br /> (Copyright © 2012 Wiley Periodicals, Inc.)
- Subjects :
- Aged
Coronary Angiography
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Myocardial Infarction etiology
Myocardial Infarction mortality
Percutaneous Coronary Intervention adverse effects
Percutaneous Coronary Intervention mortality
Proportional Hazards Models
Prospective Studies
Prosthesis Design
Rome
Sirolimus administration & dosage
Thrombosis etiology
Thrombosis mortality
Time Factors
Treatment Outcome
Cardiovascular Agents administration & dosage
Coated Materials, Biocompatible
Drug-Eluting Stents
Percutaneous Coronary Intervention instrumentation
Polymers chemistry
Sirolimus analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1522-726X
- Volume :
- 81
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
- Publication Type :
- Academic Journal
- Accession number :
- 22639426
- Full Text :
- https://doi.org/10.1002/ccd.24498