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Elevated plasma IL-6 associates with increased risk of advanced fibrosis and cholangiocarcinoma in individuals infected by Opisthorchis viverrini.
- Source :
-
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2012; Vol. 6 (5), pp. e1654. Date of Electronic Publication: 2012 May 22. - Publication Year :
- 2012
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Abstract
- Opisthorchis viverrini is considered among the most important of the food-borne trematodes due to its strong association with advanced periductal fibrosis and bile duct cancer (cholangiocarcinoma). We investigated the relationship between plasma levels of Interleukin (IL)-6 and the risk of developing advanced fibrosis and bile duct cancer from chronic Opisthorchis infection. We show that IL-6 circulates in plasma at concentrations 58 times higher in individuals with advanced fibrosis than age, sex, and nearest-neighbor matched controls and 221 times higher in individuals with bile duct cancer than controls. We also observed a dose-response relationship between increasing levels of plasma IL-6 and increasing risk of advanced fibrosis and bile duct cancer; for example, in age and sex adjusted analyses, individuals with the highest quartiles of plasma IL-6 had a 19 times greater risk of developing advanced periductal fibrosis and a 150 times greater risk of developing of bile duct cancer than individuals with no detectable level of plasma IL-6. Finally, we show that a single plasma IL-6 measurement has excellent positive predictive value for the detection of both advanced bile duct fibrosis and bile duct cancer in regions with high O. viverrini transmission. These data support our hypothesis that common mechanisms drive bile duct fibrosis and bile duct tumorogenesis from chronic O. viverrini infection. Our study also adds a unique aspect to the literature on circulating levels of IL-6 as an immune marker of hepatobiliary pathology by showing that high levels of circulating IL-6 in plasma are not related to infection with O. viverrini, but to the development of the advanced and often lethal pathologies resulting from chronic O. viverrini infection.
- Subjects :
- Adult
Animals
Bile Duct Diseases immunology
Bile Duct Diseases parasitology
Biomarkers blood
Cholangiocarcinoma immunology
Cholangiocarcinoma parasitology
Cohort Studies
Female
Fibrosis immunology
Fibrosis parasitology
Humans
Male
Middle Aged
Opisthorchiasis immunology
Opisthorchiasis parasitology
Opisthorchiasis pathology
Opisthorchis immunology
Risk Assessment
Bile Duct Diseases epidemiology
Cholangiocarcinoma epidemiology
Fibrosis epidemiology
Interleukin-6 blood
Opisthorchiasis complications
Opisthorchis pathogenicity
Plasma chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1935-2735
- Volume :
- 6
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- PLoS neglected tropical diseases
- Publication Type :
- Academic Journal
- Accession number :
- 22629477
- Full Text :
- https://doi.org/10.1371/journal.pntd.0001654