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Cell surface expression of CD25 antigen (surface IL-2 receptor α-chain) is not a prognostic marker in chronic lymphocytic leukemia: results of a retrospective study of 281 patients.
- Source :
-
Annals of hematology [Ann Hematol] 2012 Oct; Vol. 91 (10), pp. 1597-602. Date of Electronic Publication: 2012 May 24. - Publication Year :
- 2012
-
Abstract
- Using the database of the Israeli CLL Study Group, we investigated the incidence and prognostic significance of CD25 expression on the surface of lymphocytic leukemia cells. Strong CD25 expression was found in 46 (16.4 %) of 281 tested cases and was correlated with the presence of splenomegaly (p = 0.04), expression of CD38 antigen (p = 0.001), and FMC-7 (p = 0.04). Age, gender, Binet stage, circulating lymphocyte count, presence of anemia or thrombocytopenia, atypical cell morphology, serum beta 2-microglobulin level, and ZAP-70 expression did not differ in patients with or without cell surface CD25. There was no correlation between CD25 expression and time to first treatment or overall survival. CD25 expression does not appear to be a prognostic factor in CLL.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antigens, Surface biosynthesis
Biomarkers blood
Cohort Studies
Databases, Factual
Female
Follow-Up Studies
Humans
Leukemia, Lymphocytic, Chronic, B-Cell genetics
Leukemia, Lymphocytic, Chronic, B-Cell mortality
Male
Middle Aged
Prognosis
Retrospective Studies
Survival Rate trends
Gene Expression Regulation, Neoplastic
Interleukin-2 Receptor alpha Subunit biosynthesis
Leukemia, Lymphocytic, Chronic, B-Cell diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0584
- Volume :
- 91
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Annals of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 22623161
- Full Text :
- https://doi.org/10.1007/s00277-012-1492-4