Back to Search
Start Over
Lower liver-related death in African-American women with human immunodeficiency virus/hepatitis C virus coinfection, compared to Caucasian and Hispanic women.
- Source :
-
Hepatology (Baltimore, Md.) [Hepatology] 2012 Nov; Vol. 56 (5), pp. 1699-705. Date of Electronic Publication: 2012 Aug 27. - Publication Year :
- 2012
-
Abstract
- Unlabelled: Among individuals with and without concurrent human immunodeficiency virus (HIV), racial/ethnic differences in the natural history of hepatitis C virus (HCV) have been described. African Americans have lower spontaneous HCV clearance than Caucasians, yet slower rates of liver fibrosis once chronically infected. It is not clear how these differences in the natural history of hepatitis C affect mortality, in either HIV-positive or -negative individuals. We conducted a cohort study of HIV/HCV coinfected women followed in the multicenter Women's Interagency HIV Study to determine the association of self-reported race/ethnicity with all-cause and liver-related mortality. Survival analyses were performed using Cox's proportional hazards models. The eligible cohort (n = 794) included 140 Caucasians, 159 Hispanics, and 495 African Americans. There were 438 deaths and 49 liver-related deaths during a median follow-up of 8.9 years and maximum follow-up of 16 years. African-American coinfected women had significantly lower liver-related mortality, compared to Caucasian (hazard ratio [HR], 0.41; 95% confidence interval [CI]: 0.19-0.88; P = 0.022) and Hispanic coinfected women (HR, 0.38; 95% CI: 0.19-0.76; P = 0.006). All-cause mortality was similar between racial/ethnic groups (HRs for all comparisons: 0.82-1.03; log-rank test: P = 0.8).<br />Conclusions: African-American coinfected women were much less likely to die from liver disease, as compared to Caucasians and Hispanics, independent of other causes of death. Future studies are needed to investigate the reasons for this marked racial/ethnic discrepancy in liver-related mortality.<br /> (Copyright © 2012 American Association for the Study of Liver Diseases.)
- Subjects :
- Adult
CD4 Lymphocyte Count
Coinfection
Female
HIV
HIV Infections blood
HIV Infections ethnology
Hepacivirus
Hepatitis C blood
Hepatitis C ethnology
Humans
Liver Diseases ethnology
Liver Diseases mortality
Middle Aged
Multivariate Analysis
Prospective Studies
RNA, Viral blood
United States epidemiology
Black or African American statistics & numerical data
HIV Infections mortality
Hepatitis C mortality
Hispanic or Latino statistics & numerical data
White People statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1527-3350
- Volume :
- 56
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Hepatology (Baltimore, Md.)
- Publication Type :
- Academic Journal
- Accession number :
- 22618868
- Full Text :
- https://doi.org/10.1002/hep.25859