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High risk of QT interval prolongation and torsades de pointes associated with intravenous quinidine used for treatment of resistant malaria or babesiosis.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2012 Aug; Vol. 56 (8), pp. 4495-9. Date of Electronic Publication: 2012 May 21. - Publication Year :
- 2012
-
Abstract
- Cardiac toxicity may be associated with drugs used for malaria. Torsades de pointes (TdP) is a well-known adverse effect of quinidine when used for atrial fibrillation. Intravenous quinidine doses for resistant malaria are 2 to 3 times higher than those used for arrhythmias. Among 6 patients receiving quinidine for malaria or babesiosis, 4 developed QT interval prolongation and 2 experienced TdP. Clinicians should be aware that recommended doses of quinidine for malaria carry a high TdP risk.
- Subjects :
- Adolescent
Adult
Aged
Antimalarials therapeutic use
Babesiosis physiopathology
Female
Heart drug effects
Heart Rate drug effects
Humans
Malaria physiopathology
Male
Middle Aged
Quinidine therapeutic use
Risk Factors
Antimalarials adverse effects
Arrhythmias, Cardiac chemically induced
Babesiosis drug therapy
Long QT Syndrome chemically induced
Malaria drug therapy
Quinidine adverse effects
Torsades de Pointes chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 56
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 22615288
- Full Text :
- https://doi.org/10.1128/AAC.06396-11