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IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression.
- Source :
-
Metabolic brain disease [Metab Brain Dis] 2012 Dec; Vol. 27 (4), pp. 415-23. Date of Electronic Publication: 2012 May 22. - Publication Year :
- 2012
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Abstract
- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and depression are considered to be neuro-immune disorders (Maes and Twisk, BMC Medicine 8:35, 2010). There is also evidence that depression and ME/CFS are accompanied by oxidative and nitrosative stress (O&NS) and by increased autoantibodies to a number of self-epitopes some of which have become immunogenic due to damage by O&NS. The aim of this study is to examine IgM-mediated autoimmune responses to different self-epitopes in ME/CFS versus depression. We examined serum IgM antibodies to three anchorage molecules (palmitic and myristic acid and S-farnesyl-L-cysteine); acetylcholine; and conjugated NO-modified adducts in 26 patients with major depression; 16 patients with ME/CFS, 15 with chronic fatigue; and 17 normal controls. Severity of fatigue and physio-somatic (F&S) symptoms was measured with the Fibromyalgia and Chronic Fatigue Syndrome Rating Scale. Serum IgM antibodies to the three anchorage molecules and NO-phenylalanine were significantly higher in ME/CFS than in depression. The autoimmune responses to oxidatively, but not nitrosatively, modified self-epitopes were significantly higher in ME/CFS than in depression and were associated with F&S symptoms. The autoimmune activity directed against conjugated acetylcholine did not differ significantly between ME/CFS and depression, but was greater in the patients than controls. Partially overlapping pathways, i.e. increased IgM antibodies to a multitude of neo-epitopes, underpin both ME/CFS and depression, while greater autoimmune responses directed against anchorage molecules and oxidatively modified neo-epitopes discriminate patients with ME/CFS from those with depression. These autoimmune responses directed against neoantigenic determinants may play a role in the dysregulation of key cellular functions in both disorders, e.g. intracellular signal transduction, cellular differentiation and apoptosis, but their impact may be more important in ME/CFS than in depression.
- Subjects :
- Adult
Amino Acids metabolism
Analysis of Variance
Autoimmune Diseases psychology
Cysteine metabolism
Depressive Disorder, Major psychology
Enzyme-Linked Immunosorbent Assay
Epitopes immunology
Fatigue Syndrome, Chronic psychology
Female
Humans
Least-Squares Analysis
Male
Middle Aged
Nitric Oxide metabolism
Phenylalanine metabolism
Autoimmune Diseases immunology
Cysteine analogs & derivatives
Depressive Disorder, Major immunology
Fatigue Syndrome, Chronic immunology
Immunoglobulin M immunology
Myristic Acid metabolism
Palmitic Acid metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7365
- Volume :
- 27
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Metabolic brain disease
- Publication Type :
- Academic Journal
- Accession number :
- 22614823
- Full Text :
- https://doi.org/10.1007/s11011-012-9316-8