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Pancreatic insufficiency is not a prevalent problem in Alagille syndrome.
- Source :
-
Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2012 Nov; Vol. 55 (5), pp. 612-4. - Publication Year :
- 2012
-
Abstract
- Alagille syndrome (ALGS) is an inherited multisystem disorder in which pancreatic insufficiency (PI) has been regarded a minor but important clinical manifestation. As part of a multicenter prospective study, 42 patients with ALGS underwent fecal elastase (FE) measurement to screen for exocrine PI. FE measurements were normal (>200 μg/g) in 40 (95%) and indeterminate (100-200 μg/g) in 2 (5%). As FE is the most reliable screen for PI, these data suggest that PI is not a prevalent problem in ALGS.
- Subjects :
- Adolescent
Adult
Alagille Syndrome metabolism
Biomarkers metabolism
Child
Child, Preschool
Exocrine Pancreatic Insufficiency epidemiology
Exocrine Pancreatic Insufficiency metabolism
Humans
Prevalence
Prospective Studies
Young Adult
Alagille Syndrome complications
Exocrine Pancreatic Insufficiency etiology
Feces chemistry
Pancreatic Elastase metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1536-4801
- Volume :
- 55
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of pediatric gastroenterology and nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 22614108
- Full Text :
- https://doi.org/10.1097/MPG.0b013e31825eff61