GHEP-ISFG proficiency test 2011: Paper challenge on evaluation of mitochondrial DNA results.

Authors :: Prieto L
Alves C
Zimmermann B
Tagliabracci A
Prieto V
Montesino M
Whittle MR
Anjos MJ
Cardoso S
Heinrichs B
Hernandez A
López-Parra AM
Sala A
Saragoni VG
Burgos G
Marino M
Paredes M
Mora-Torres CA
Angulo R
Chemale G
Vullo C
Sánchez-Simón M
Comas D
Puente J
López-Cubría CM
Modesti N
Aler M
Merigioli S
Betancor E
Pedrosa S
Plaza G
Masciovecchio MV
Schneider PM
Parson W
Source :: Forensic science international. Genetics [Forensic Sci Int Genet] 2013 Jan; Vol. 7 (1), pp. 10-5. Date of Electronic Publication: 2012 May 19.
Publication Year :: 2013
Abstract: The GHEP-ISFG Working Group performed a collaborative exercise to monitor the current practice of mitochondrial (mt)DNA reporting. The participating laboratories were invited to evaluate a hypothetical case example and assess the statistical significance of a match between the haplotypes of a case (hair) sample and a suspect. A total of 31 forensic laboratories participated of which all but one used the EMPOP database. Nevertheless, we observed a tenfold range of reported LR values (32-333.4), which was mainly due to the selection of different reference datasets in EMPOP but also due to different applied formulae. The results suggest the need for more standardization as well as additional research to harmonize the reporting of mtDNA evidence.<br /> (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)

Subjects :: Databases, Genetic
Haplotypes
Humans
DNA, Mitochondrial genetics

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