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OM-8980 and D-penicillamine in the treatment of rheumatoid arthritis. A 12-month double-blind randomized study.
- Source :
-
Scandinavian journal of rheumatology [Scand J Rheumatol] 1990; Vol. 19 (6), pp. 422-31. - Publication Year :
- 1990
-
Abstract
- Forty patients with active rheumatoid arthritis were included in this monocentre double-blind study comparing the therapeutic efficacy and safety of the immunomodulator OM-8980 with that of D-penicillamine. After 12 months of treatment, the parameters of Ritchie index, duration of morning stiffness, pain assessed by a visual analogue scale and categories, number of swollen joints, grip strength and erythrocyte sedimentation rate (ESR) were all significantly improved with OM-8980, as was the case for the Ritchie index, number of swollen joints and ESR with D-penicillamine. Significant intergroup differences were recorded for pain categories in favour of OM-8980 and for the Ritchie index and number of swollen joints in favour of D-penicillamine. The need for concomitant anti-inflammatory therapies and the assessment of efficacy by physicians and patients did not differ significantly between the two groups. OM-8980 was significantly better tolerated than D-penicillamine (5 patients with 5 side effects as compared with 12 patients with 16 side effects). OM-8980 can thus be regarded as an efficient and well-tolerated slow-acting drug for the treatment of rheumatoid arthritis.
- Subjects :
- Adjuvants, Immunologic administration & dosage
Adjuvants, Immunologic adverse effects
Adult
Aged
Analysis of Variance
Arthritis, Rheumatoid therapy
Chi-Square Distribution
Delayed-Action Preparations
Female
Humans
Male
Middle Aged
Penicillamine administration & dosage
Penicillamine adverse effects
Prospective Studies
Adjuvants, Immunologic therapeutic use
Antigens, Bacterial
Arthritis, Rheumatoid drug therapy
Penicillamine therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0300-9742
- Volume :
- 19
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 2259898
- Full Text :
- https://doi.org/10.3109/03009749009097631