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Beta-testing of PI3-kinase inhibitors: is beta better?
- Source :
-
Cancer discovery [Cancer Discov] 2012 May; Vol. 2 (5), pp. 393-4. - Publication Year :
- 2012
-
Abstract
- Although it has been known for some time that PTEN-null tumors require expression of the p110β isoform of phosphoinositide 3-kinase for growth, the corollary demonstration that small-molecule inhibitors of p110β are effective drugs for such tumors has not been shown. This has now been rectified by the demonstration that the TGX221 analogue KIN-193 is effective in mouse xenografts of HCC70 and PC3 human tumor cell lines.<br /> (© 2012 AACR.)
Details
- Language :
- English
- ISSN :
- 2159-8290
- Volume :
- 2
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cancer discovery
- Publication Type :
- Academic Journal
- Accession number :
- 22588874
- Full Text :
- https://doi.org/10.1158/2159-8290.CD-12-0122