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Determinants of response to triple therapy of telaprevir, peginterferon, and ribavirin in previous non-responders infected with HCV genotype 1.
- Source :
-
Journal of medical virology [J Med Virol] 2012 Jul; Vol. 84 (7), pp. 1097-105. - Publication Year :
- 2012
-
Abstract
- Patients who do not achieve sustained virological response to telaprevir/peginterferon (PEG-IFN)/ribavirin need to be identified. Predictive factors of virological response to the triple therapy in non-responders to previous PEG-IFN/ribavirin therapy are not clear. The aims of this study were to determine the predictive factors of virological response to a 24-week regimen of triple therapy in 15 non-responders to previous PEG-IFN/ribavirin therapy among 61 Japanese adults infected with HCV genotype 1. Overall, sustained virological response and end-of-treatment response were achieved by 27% and 60%, respectively. Telaprevir-resistant variants (by direct sequencing) appeared during or after treatment in 82% of patients who did not show sustained virological response, but disappeared at the end of study, except for one patient with resistant variant at baseline. Substitution at aa 70 (Arg70) and type of previous response to PEG-IFN/ribavirin (partial response) were identified as significant determinants of sustained virological response. In addition, alpha-fetoprotein level (<10 µg/L) and type of previous response (partial response) were identified as significant determinants of end-of-treatment response. Prediction of response to therapy based on the combination of these factors had high sensitivity, specificity, positive, and negative predictive values. In conclusion, this study identified amino acid substitution of the core region, alpha-fetoprotein level, and type of previous response as predictors of virological response to telaprevir/PEG-IFN/ribavirin in patients infected with HCV genotype 1b who had not responded to previous PEG-IFN/ribavirin therapy.<br /> (Copyright © 2012 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Aged
Drug Resistance, Viral
Female
Genotype
Hepacivirus classification
Hepacivirus genetics
Hepatitis C, Chronic virology
Humans
Japan
Male
Middle Aged
Predictive Value of Tests
Sensitivity and Specificity
Treatment Outcome
Antiviral Agents administration & dosage
Hepacivirus isolation & purification
Hepatitis C, Chronic drug therapy
Interferons administration & dosage
Oligopeptides administration & dosage
Ribavirin administration & dosage
Virology methods
Subjects
Details
- Language :
- English
- ISSN :
- 1096-9071
- Volume :
- 84
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of medical virology
- Publication Type :
- Academic Journal
- Accession number :
- 22585728
- Full Text :
- https://doi.org/10.1002/jmv.23262