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Green tea halts progression of cardiac transthyretin amyloidosis: an observational report.
- Source :
-
Clinical research in cardiology : official journal of the German Cardiac Society [Clin Res Cardiol] 2012 Oct; Vol. 101 (10), pp. 805-13. Date of Electronic Publication: 2012 May 15. - Publication Year :
- 2012
-
Abstract
- Background: Treatment options in patients with amyloidotic transthyretin (ATTR) cardiomyopathy are limited. Epigallocatechin-3-gallate (EGCG), the most abundant catechin in green tea (GT), inhibits fibril formation from several amyloidogenic proteins in vitro. Thus, it might also halt progression of TTR amyloidosis. This is a single-center observational report on the effects of GT consumption in patients with ATTR cardiomopathy.<br />Methods: 19 patients with ATTR cardiomyopathy were evaluated by standard blood tests, echocardiography, and cardiac MRI (n = 9) before and after consumption of GT and/or green tea extracts (GTE) for 12 months.<br />Results: Five patients were not followed up for reasons of death (n = 2), discontinuation of GT/GTE consumption (n = 2), and heart transplantation (n = 1). After 12 months no increase of left ventricular (LV) wall thickness and LV myocardial mass was observed by echocardiography. In the subgroup of patients evaluated by cardiac MRI a mean decrease of LV myocardial mass (-12.5 %) was detected in all patients. This was accompanied by an increase of mean mitral annular systolic velocity of 9 % in all 14 patients. Total cholesterol (191.9 ± 8.9 vs. 172.7 ± 9.4 mg/dL; p < 0.01) and LDL cholesterol (105.8 ± 7.6 vs. 89.5 ± 8.0 mg/dL; p < 0.01) decreased significantly during the observational period. No serious adverse effects were reported by any of the participants.<br />Conclusions: Our observation suggests an inhibitory effect of GT and/or GTE on the progression of cardiac amyloidosis. We propose a randomized placebo-controlled investigation to confirm our observation.
- Subjects :
- Aged
Amyloid Neuropathies, Familial physiopathology
Cardiomyopathies physiopathology
Catechin isolation & purification
Catechin pharmacology
Cholesterol blood
Cohort Studies
Disease Progression
Female
Follow-Up Studies
Heart Ventricles drug effects
Heart Ventricles pathology
Humans
Male
Middle Aged
Mitral Valve metabolism
Plant Extracts pharmacology
Amyloid Neuropathies, Familial drug therapy
Cardiomyopathies drug therapy
Catechin analogs & derivatives
Tea chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1861-0692
- Volume :
- 101
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Clinical research in cardiology : official journal of the German Cardiac Society
- Publication Type :
- Academic Journal
- Accession number :
- 22584381
- Full Text :
- https://doi.org/10.1007/s00392-012-0463-z