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A novel bitriazolyl acyclonucleoside endowed with dual antiproliferative and immunomodulatory activity.
A novel bitriazolyl acyclonucleoside endowed with dual antiproliferative and immunomodulatory activity.
- Source :
-
Journal of medicinal chemistry [J Med Chem] 2012 Jun 14; Vol. 55 (11), pp. 5642-6. Date of Electronic Publication: 2012 May 21. - Publication Year :
- 2012
-
Abstract
- A novel bitriazolyl acyclonucleoside was discovered to exhibit powerful antiproliferative effects on different cancer cell lines through caspase-dependent apoptosis and at the same time stimulate the immune response in dendritic cells via Toll-like receptor 7 (TLR7) signaling. This promising compound with dual anticancer and immunomodulatory activity may represent a new generation of highly efficacious drug candidates for use in cancer therapy.
- Subjects :
- Animals
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Apoptosis drug effects
Cell Line, Tumor
Dendritic Cells drug effects
Dendritic Cells immunology
Dendritic Cells metabolism
Drug Resistance, Neoplasm
Drug Screening Assays, Antitumor
Humans
Immunologic Factors chemistry
Immunologic Factors pharmacology
Interleukin-6 biosynthesis
Membrane Glycoproteins genetics
Membrane Glycoproteins metabolism
Mice
Mice, Knockout
Nucleosides chemistry
Nucleosides pharmacology
Structure-Activity Relationship
Toll-Like Receptor 7 genetics
Toll-Like Receptor 7 metabolism
Triazoles chemistry
Triazoles pharmacology
Antineoplastic Agents chemical synthesis
Immunologic Factors chemical synthesis
Nucleosides chemical synthesis
Triazoles chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1520-4804
- Volume :
- 55
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 22578090
- Full Text :
- https://doi.org/10.1021/jm300534u