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Anticonvulsant action of an arylamine-containing fraction from Agelenopsis spider venom.
- Source :
-
Brain research [Brain Res] 1990 Sep 03; Vol. 526 (2), pp. 338-41. - Publication Year :
- 1990
-
Abstract
- A low molecular weight fraction (AG2) containing arylamine compounds has been isolated from venom of the spider Agelenopsis aperta. When administered intravenously or intracerebroventricularly, AG2 produces dose-dependent suppression of behavioral convulsions induced in rats by kainic acid, picrotoxin, or bicuculline. The low molecular weight compounds in spider venoms may provide novel tools for anticonvulsant research and therapy.
- Subjects :
- Animals
Bicuculline antagonists & inhibitors
Biogenic Amines isolation & purification
Chemical Fractionation
Dose-Response Relationship, Drug
Injections, Intravenous
Injections, Intraventricular
Kainic Acid antagonists & inhibitors
Male
Molecular Weight
Picrotoxin antagonists & inhibitors
Rats
Rats, Inbred Strains
Anticonvulsants
Biogenic Amines pharmacology
Spider Venoms analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 526
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 2257489
- Full Text :
- https://doi.org/10.1016/0006-8993(90)91243-a