Back to Search
Start Over
Immunological characteristics and response to lipopolysaccharide of mouse lines selectively bred with natural and acquired immunities.
- Source :
-
Animal science journal = Nihon chikusan Gakkaiho [Anim Sci J] 2012 May; Vol. 83 (5), pp. 367-74. Date of Electronic Publication: 2011 Nov 16. - Publication Year :
- 2012
-
Abstract
- Genetic improvement of resistance to infectious diseases is a challenging goal in animal breeding. Infection resistance involves multiple immunological characteristics, including natural and acquired immunity. In the present study, we developed an experimental model based on genetic selection, to improve immunological phenotypes. We selectively established three mouse lines based on phagocytic activity, antibody production and the combination of these two phenotypes. We analyzed the immunological characteristics of these lines using a lipopolysaccharide (LPS), which is one of the main components of Gram-negative bacteria. An intense immunological reaction was induced in each of the three mouse lines. Severe loss of body weight and liver damage were observed, and a high level of cytokine messenger RNA was detected in the liver tissue. The mouse line established using a combination of the two selection standards showed unique characteristics relative to the mouse lines selected on the basis of a single phenotype. Our results indicate that genetic selection and breeding is effective, even for immunological phenotypes with a relatively low heritability. Thus, it may be possible to improve resistance to infectious diseases by means of genetic selection.<br /> (© 2011 The Authors. Animal Science Journal © 2011 Japanese Society of Animal Science.)
- Subjects :
- Animals
Antibody Formation physiology
Bacterial Infections
Cytokines analysis
Disease Susceptibility
Genetic Predisposition to Disease genetics
Mice
Phagocytosis
Phenotype
Real-Time Polymerase Chain Reaction
Transaminases metabolism
Adaptive Immunity
Immunity, Innate
Lipopolysaccharides immunology
Selection, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 1740-0929
- Volume :
- 83
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Animal science journal = Nihon chikusan Gakkaiho
- Publication Type :
- Academic Journal
- Accession number :
- 22574788
- Full Text :
- https://doi.org/10.1111/j.1740-0929.2011.00980.x