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Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training.
- Source :
-
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2012 Jul 15; Vol. 303 (2), pp. R127-34. Date of Electronic Publication: 2012 May 09. - Publication Year :
- 2012
-
Abstract
- A decline in mitochondrial biogenesis and mitochondrial protein quality control in skeletal muscle is a common finding in aging, but exercise training has been suggested as a possible cure. In this report, we tested the hypothesis that moderate-intensity exercise training could prevent the age-associated deterioration in mitochondrial biogenesis in the gastrocnemius muscle of Wistar rats. Exercise training, consisting of treadmill running at 60% of the initial Vo(2max), reversed or attenuated significant age-associated (detrimental) declines in mitochondrial mass (succinate dehydrogenase, citrate synthase, cytochrome-c oxidase-4, mtDNA), SIRT1 activity, AMPK, pAMPK, and peroxisome proliferator-activated receptor gamma coactivator 1-α, UCP3, and the Lon protease. Exercise training also decreased the gap between young and old animals in other measured parameters, including nuclear respiratory factor 1, mitochondrial transcription factor A, fission-1, mitofusin-1, and polynucleotide phosphorylase levels. We conclude that exercise training can help minimize detrimental skeletal muscle aging deficits by improving mitochondrial protein quality control and biogenesis.
- Subjects :
- Adaptation, Physiological physiology
Animals
Male
Membrane Proteins metabolism
Models, Animal
Nuclear Respiratory Factor 1 metabolism
Rats
Rats, Wistar
Transcription Factors metabolism
Aging metabolism
Mitochondria, Muscle metabolism
Mitochondrial Proteins metabolism
Muscle, Skeletal metabolism
Physical Conditioning, Animal
Subjects
Details
- Language :
- English
- ISSN :
- 1522-1490
- Volume :
- 303
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Regulatory, integrative and comparative physiology
- Publication Type :
- Academic Journal
- Accession number :
- 22573103
- Full Text :
- https://doi.org/10.1152/ajpregu.00337.2011