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Common use of anticholinergic medications in older patients with schizophrenia: findings of the Research on Asian Psychotropic Prescription Pattern (REAP) study, 2001-2009.

Authors :
Xiang YT
Dickerson F
Kreyenbuhl J
Ungvari GS
Wang CY
Si TM
Lee EH
Chiu HF
Lai KY
He YL
Yang SY
Chong MY
Tan CH
Kua EH
Fujii S
Sim K
Yong MK
Trivedi JK
Chung EK
Udomratn P
Chee KY
Sartorius N
Shinfuku N
Source :
International journal of geriatric psychiatry [Int J Geriatr Psychiatry] 2013 Mar; Vol. 28 (3), pp. 305-11. Date of Electronic Publication: 2012 May 07.
Publication Year :
2013

Abstract

Objective: This study surveyed the use of anticholinergic medications (ACMs) in older Asian patients with schizophrenia and examined its demographic and clinical correlates.<br />Method: A total of 1452 hospitalized patients with schizophrenia aged 55 years or older in nine Asian countries and territories were surveyed between 2001 and 2009. The cross-sectional data of patients' socio-demographic and clinical characteristics and the prescriptions of antipsychotic drugs and ACM were recorded using a standardized protocol and data collection procedure.<br />Results: The frequency of ACM prescription was 64.6% in the pooled sample, with 72.4%, 61.9%, and 59.5% in 2001, 2004, and 2009, respectively. Multiple logistic regression analysis of the whole sample revealed that patients on ACM had a higher dose of antipsychotic medications, and were more likely to have extrapyramidal side effects and receive first-generation antipsychotic medications.<br />Conclusions: Anticholinergic medications were frequently used in older Asian patients with schizophrenia. Considering the potential side effects of ACM, the rationale for their widespread use in this patient population should be revisited.<br /> (Copyright © 2012 John Wiley & Sons, Ltd.)

Details

Language :
English
ISSN :
1099-1166
Volume :
28
Issue :
3
Database :
MEDLINE
Journal :
International journal of geriatric psychiatry
Publication Type :
Academic Journal
Accession number :
22565547
Full Text :
https://doi.org/10.1002/gps.3827