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Recent progress in vaccines against fungal diseases.
- Source :
-
Current opinion in microbiology [Curr Opin Microbiol] 2012 Aug; Vol. 15 (4), pp. 427-33. Date of Electronic Publication: 2012 May 06. - Publication Year :
- 2012
-
Abstract
- Diseases caused by fungi are increasingly impacting the health of the human population and now account for a large fraction of infectious disease complications in individuals with impaired immunity or breached tissue defenses. Antifungal therapy is often of limited effectiveness in these patients, resulting into treatment failures, chronic infections and unacceptable rates of mortality, morbidity and their associated costs. Consequently there is a real medical need for new treatments and preventive measures to combat fungal diseases and, toward this goal, safe and efficacious vaccines would constitute major progress. After decades of complacency and neglect of this critically important field of research, remarkable progress has been made in recent years. A number of highly immunogenic and protective vaccine formulations in preclinical setting have been developed, and at least two have undergone Phase 1 clinical trials as preventive and/or therapeutic tools against candidiasis.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Aspergillosis immunology
Aspergillosis prevention & control
Candidiasis, Vulvovaginal immunology
Candidiasis, Vulvovaginal prevention & control
Cryptococcosis immunology
Cryptococcosis prevention & control
Female
Fungi immunology
Humans
Fungal Vaccines administration & dosage
Fungal Vaccines immunology
Fungal Vaccines therapeutic use
Mycoses immunology
Mycoses prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0364
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Current opinion in microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 22564747
- Full Text :
- https://doi.org/10.1016/j.mib.2012.04.004