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Evaluation of bleeding-related episodes in patients with immune thrombocytopenia (ITP) receiving romiplostim or medical standard of care.
- Source :
-
International journal of hematology [Int J Hematol] 2012 Jul; Vol. 96 (1), pp. 26-33. Date of Electronic Publication: 2012 May 05. - Publication Year :
- 2012
-
Abstract
- Romiplostim increases platelet counts and reduces the risk of bleeding in patients with immune thrombocytopenia (ITP). This post hoc analysis compared the effect of romiplostim versus medical standard of care (SOC) on clinically relevant bleeding-related episodes (BREs) in a 52-week open-label study of patients with ITP. BREs were defined as actual bleeding events and/or use of rescue medication. Nonsplenectomized adult patients with ITP were randomized to receive weekly subcutaneous injections of romiplostim (n = 157) or SOC (n = 77). The rate of all BREs (per 100 patient-weeks) was lower in patients treated with romiplostim (3.1) than in those treated with SOC (9.4); the relative rate (romiplostim/SOC) was 0.33 (95 % CI 0.27-0.40). The rate of BREs associated with immunoglobulin (Ig) rescue medication was also lower for romiplostim (0.2) than SOC (4.8); the relative rate (romiplostim/SOC) was 0.05 (95 % CI 0.03-0.08). BRE rates were lower in patients with platelet counts ≥50 × 10(9)/L, and patients treated with romiplostim spent more time with platelet counts ≥50 × 10(9)/L than did patients treated with SOC. Bleeding-related hospitalizations were rare in both groups. Thus, romiplostim treatment provided greater reductions in all BREs, as well as BREs involving Ig rescue medications, than did SOC.
- Subjects :
- Aged
Aged, 80 and over
Female
Hemorrhage epidemiology
Humans
Immunoglobulins, Intravenous therapeutic use
Incidence
Male
Middle Aged
Platelet Count
Receptors, Thrombopoietin agonists
Hemorrhage etiology
Purpura, Thrombocytopenic, Idiopathic complications
Purpura, Thrombocytopenic, Idiopathic therapy
Receptors, Fc therapeutic use
Recombinant Fusion Proteins therapeutic use
Standard of Care
Thrombopoietin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1865-3774
- Volume :
- 96
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 22562409
- Full Text :
- https://doi.org/10.1007/s12185-012-1088-8