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The MRL proteins: adapting cell adhesion, migration and growth.

Authors :
Coló GP
Lafuente EM
Teixidó J
Source :
European journal of cell biology [Eur J Cell Biol] 2012 Nov-Dec; Vol. 91 (11-12), pp. 861-8. Date of Electronic Publication: 2012 May 01.
Publication Year :
2012

Abstract

MIG-10, RIAM and Lamellipodin (Lpd) are the founding members of the MRL family of multi-adaptor molecules. These proteins have common domain structures but display distinct functions in cell migration and adhesion, signaling, and in cell growth. The binding of RIAM with active Rap1 and with talin provides these MRL molecules with important regulatory roles on integrin-mediated cell adhesion and migration. Furthermore, RIAM and Lpd can regulate actin dynamics through their binding to actin regulatory Ena/VASP proteins. Recent data generated with the Drosophila MRL ortholog called Pico and with RIAM in melanoma cells indicate that these proteins can also regulate cell growth. As MRL proteins represent a relatively new family, many questions on their structure-function relationships remain unanswered, including regulation of their expression, post-translational modifications, new interactions, involvement in signaling and their knockout mice phenotype.<br /> (Copyright © 2012 Elsevier GmbH. All rights reserved.)

Details

Language :
English
ISSN :
1618-1298
Volume :
91
Issue :
11-12
Database :
MEDLINE
Journal :
European journal of cell biology
Publication Type :
Academic Journal
Accession number :
22555291
Full Text :
https://doi.org/10.1016/j.ejcb.2012.03.001