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Prognostic significances of estrogen and progesterone receptors in primary operable breast cancer.

Prognostic significances of estrogen and progesterone receptors in primary operable breast cancer.

Authors :
Kurebayashi J
Ishida T
Higashi Y
Suemasu K
Nomoto C
Yoshida K
Source :
Japanese journal of clinical oncology [Jpn J Clin Oncol] 1990 Sep; Vol. 20 (3), pp. 271-80.
Publication Year :
1990

Abstract

Both estrogen and progesterone receptors have been determined in 613 primary breast cancer patients treated by radical mastectomy. At the cut-off value of 5 fentomoles (fmol) cytosol protein/mg for both receptors, patients with estrogen or progesterone receptor-positive breast cancer showed significantly favorable disease-free, overall and post-recurrence survival curves to those of receptor-negative breast cancer patients. In the patient subgroups: premenopausal, stage III, more than four positive lymph node metastases, postoperative adjuvant tamoxifen therapy, a significantly favorable prognosis was recognized in either estrogen or progesterone receptor-positive patients. Both receptors are thought to be useful prognostic indicators for patients with advanced tumors or for those receiving postoperative adjuvant tamoxifen therapy. When the cut-off value was changed, the maximum significant difference in prognosis between receptor-positive and receptor-negative patients was observed at 5 fmol cytosol protein/mg for the estrogen receptor or 10 fmol/mg cytosol protein for the progesterone receptor. A more detailed examination should be made on the cut-off values of both receptors.

Details

Language :
English
ISSN :
0368-2811
Volume :
20
Issue :
3
Database :
MEDLINE
Journal :
Japanese journal of clinical oncology
Publication Type :
Academic Journal
Accession number :
2255103