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Cell type-specific eQTLs in the human immune system.

Authors :
Gregersen PK
Source :
Nature genetics [Nat Genet] 2012 Apr 26; Vol. 44 (5), pp. 478-80. Date of Electronic Publication: 2012 Apr 26.
Publication Year :
2012

Abstract

A new study reports the mapping of gene expression in primary immune cell subsets, showing the presence of cell type-specific cis and trans expression quantitative trait loci (eQTLs). The identification of cell type-specific trans-regulated networks can inform functional studies of susceptibility loci identified from genome-wide association studies for human complex diseases.

Details

Language :
English
ISSN :
1546-1718
Volume :
44
Issue :
5
Database :
MEDLINE
Journal :
Nature genetics
Publication Type :
Academic Journal
Accession number :
22538719
Full Text :
https://doi.org/10.1038/ng.2258