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Bacterial infections, DNA virus infections, and RNA virus infections manifest differently in neutrophil receptor expression.
- Source :
-
TheScientificWorldJournal [ScientificWorldJournal] 2012; Vol. 2012, pp. 527347. Date of Electronic Publication: 2012 Mar 12. - Publication Year :
- 2012
-
Abstract
- Treating viral illnesses or noninfective causes of inflammation with antibiotics is ineffective and contributes to the development of antibiotic resistance, toxicity, and allergic reactions, leading to increasing medical costs. A major factor behind unnecessary use of antibiotics is, of course, incorrect diagnosis. For this reason, timely and accurate information on whether the infection is bacterial in origin would be highly beneficial. In this paper we will present our recent studies on the expression of opsonin receptors on phagocytes. The analysis of the expression levels of FcγRI, CR1, and CR3, along with CRP and ESR data, provides a novel application to the diagnosis of infectious and inflammatory diseases. The best clinical benefit will be obtained when the individual variables are combined to generate the CIS point method for a bacterial infection marker, DNAVS point for differentiating between DNA and RNA virus infections, and CRP/CD11b ratio for a marker of Gram-positive sepsis.
- Subjects :
- Adult
Aged
Bacterial Infections diagnosis
DNA Virus Infections diagnosis
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Prospective Studies
RNA Virus Infections diagnosis
Bacterial Infections immunology
DNA Virus Infections immunology
Neutrophils immunology
RNA Virus Infections immunology
Receptors, Immunologic immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-744X
- Volume :
- 2012
- Database :
- MEDLINE
- Journal :
- TheScientificWorldJournal
- Publication Type :
- Academic Journal
- Accession number :
- 22536142
- Full Text :
- https://doi.org/10.1100/2012/527347