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Haematopoietic stem cell transplantation (HSCT) in severe autoimmune diseases: analysis of UK outcomes from the British Society of Blood and Marrow Transplantation (BSBMT) data registry 1997-2009.
- Source :
-
British journal of haematology [Br J Haematol] 2012 Jun; Vol. 157 (6), pp. 742-6. Date of Electronic Publication: 2012 Apr 26. - Publication Year :
- 2012
-
Abstract
- The British Society of Blood and Marrow Transplantation Data Registry was used to analyse outcomes of haematopoietic stem cell transplantation (HSCT) in severe autoimmune diseases (SADs) from 1997 to 2009. 55 autologous and 15 allogeneic HSCT were registered (0·22% of overall UK HSCT activity). Sustained responses were observed following HSCT, although toxicity was significant. This is the first reported national analysis of long-term outcomes of HSCT in SADs, and should be viewed in the context of translational and developmental phases of HSCT in poor prognosis and refractory SADs. Treatment of poor-risk but reversible SADs with adequate fitness for HSCT in accordance with current guidelines is warranted.<br /> (© 2012 Blackwell Publishing Ltd.)
- Subjects :
- Adolescent
Adult
Aged
Child
Child, Preschool
Disease-Free Survival
Female
Humans
Infant
Male
Middle Aged
Retrospective Studies
Societies, Medical
Survival Rate
Transplantation, Homologous
United Kingdom epidemiology
Autoimmune Diseases mortality
Autoimmune Diseases therapy
Hematopoietic Stem Cell Transplantation
Registries
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2141
- Volume :
- 157
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 22533715
- Full Text :
- https://doi.org/10.1111/j.1365-2141.2012.09122.x