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Association of multi-pathogenic infections with BAT2, CXCL12, Mx1 and EHMT2 variations in pigs.
- Source :
-
Molecular biology reports [Mol Biol Rep] 2012 Aug; Vol. 39 (8), pp. 8169-76. Date of Electronic Publication: 2012 Apr 25. - Publication Year :
- 2012
-
Abstract
- Porcine reproductive and respiratory syndrome virus (PRRSV), Haemophilus parasuis and Pseudorabies become a widespread problem causing great economic losses associated with reproductive disturbance, respiratory diseases, neonatal mortality, fibrinous polyserositis, meningitis and arthritis in the pig industry. The important candidate genes are assumed to play crucial roles in host defense against the diseases. The aims of this study were to evaluate the variants in HLA-B associated transcript 2 (BAT2), CXCL12, myxovirus resistance protein 1 (Mx1) and EHMT2 genes and their effects on the risk of infection PRRSV and H. parasuis in a case-control (diseased-healthy pigs) population of Duroc × Landrace × LargeWhite. The results showed that the mutations in BAT2, Mx1 and EHMT2 genes were significantly associated with the antibody and the reisk of infection PRRSV and H. parasuis. Those individuals with AA genotype of BAT2 had significantly higher Pseudorabies virus antibody than that with GG and GA (P < 0.05), and the individuals with TT genotype of EHMT2 generated higher Hog Cholera and Pseudorabies virus antibody than that wtih GG and GA (P < 0.01). These results indicated that the polymorphisms in Mx1, BAT2 and EHMT2 genes changed the diseases susceptibility and could be the potential markers assisting the pig breeding selection and disease resistance.
- Subjects :
- Animals
Antibodies, Bacterial immunology
Antibodies, Viral immunology
Case-Control Studies
Disease Resistance genetics
Disease Resistance immunology
Genetic Predisposition to Disease
Haemophilus Infections veterinary
Incidence
Myxovirus Resistance Proteins
Porcine Reproductive and Respiratory Syndrome genetics
Porcine Reproductive and Respiratory Syndrome immunology
Pseudorabies genetics
Pseudorabies immunology
Swine
Swine Diseases epidemiology
Swine Diseases immunology
Chemokine CXCL12 genetics
GTP-Binding Proteins genetics
Histone-Lysine N-Methyltransferase genetics
Polymorphism, Single Nucleotide
Swine Diseases genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4978
- Volume :
- 39
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Molecular biology reports
- Publication Type :
- Academic Journal
- Accession number :
- 22531939
- Full Text :
- https://doi.org/10.1007/s11033-012-1664-2