Back to Search Start Over

β-TrCP dependency of HIV-1 Vpu-induced downregulation of CD4 and BST-2/tetherin.

Authors :
Blanchet FP
Mitchell JP
Piguet V
Source :
Current HIV research [Curr HIV Res] 2012 Jun; Vol. 10 (4), pp. 307-14.
Publication Year :
2012

Abstract

During evolution, pathogens have evolved strategies to counteract key cellular restriction mechanisms in order to efficiently invade target cells and fulfill essential steps of their replication cycle. Human Immunodeficiency Virus-1 and some Simian counterparts express a small multifunctional protein, Vpu, which influences viral replication. By acting as a multifunctional adapter, Vpu enhances viral particle release and infectivity. Therefore Vpu, an accessory protein, contributes to pathogenesis while avoiding superinfection. These effects rely mainly on the ability of Vpu to target the host proteins CD4 and BST-2/tetherin. Indeed, Vpu downregulates the cell surface expression of these receptors and subsequently induces their proteolysis via a mechanism involving a β -TrCP-containing E3 ubiquitin ligase complex. In this review, we will detail recent research aimed at elucidating the mechanism of Vpu-mediated CD4 and BST-2/tetherin downregulation and degradation as well as their subsequent consequences on viral pathogenesis.

Details

Language :
English
ISSN :
1873-4251
Volume :
10
Issue :
4
Database :
MEDLINE
Journal :
Current HIV research
Publication Type :
Academic Journal
Accession number :
22524179
Full Text :
https://doi.org/10.2174/157016212800792441