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Lack of prognostic significance of angiogenesis in canine melanocytic tumours.
- Source :
-
Journal of comparative pathology [J Comp Pathol] 2012 Aug-Oct; Vol. 147 (2-3), pp. 147-52. Date of Electronic Publication: 2012 Apr 19. - Publication Year :
- 2012
-
Abstract
- The prognostic significance of angiogenesis in some canine tumours has been investigated, but little is known about its relevance in canine melanocytic tumours (MTs). The aim of this study was to evaluate the prognostic significance of angiogenesis in canine MTs. A total of 36 cutaneous melanocytomas (benign MTs), 40 cutaneous melanomas (malignant MTs) and 43 oral melanomas were studied. Survival data were available for a subset of 59 cases. Microvessel density (MVD) and endothelial area (EA) were determined by immunolabelling using an antibody specific for von Willebrand factor (vWF). Mean MVD (expressed as the number of microvessels per mm(2)) was 129 ± 14 in melanocytomas, 191 ± 16 in cutaneous melanomas and 208 ± 16 in oral melanomas. Mean EA (expressed as the percentage of the total area) was 1.5 ± 0.14 in melanocytomas, 2.6 ± 0.2 in cutaneous melanomas and 2.4 ± 0.3 in oral melanomas. The differences in MVD and EA between melanocytomas and melanomas were significant (P = 0.001 and P = 0.003, respectively). MVD and EA were significantly correlated between cutaneous and oral MTs (r = 0.54; P <0.001 and r = 0.63; P <0.001, respectively). MVD and EA were not related to survival in cutaneous and oral MTs. In conclusion, tumour vascularization was higher in melanomas than in melanocytomas, but it seemed to have no prognostic significance in these tumours.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Argentina epidemiology
Dog Diseases metabolism
Dog Diseases mortality
Dogs
Melanocytes pathology
Melanoma blood supply
Melanoma diagnosis
Melanoma mortality
Microvessels pathology
Mouth Neoplasms blood supply
Mouth Neoplasms diagnosis
Mouth Neoplasms mortality
Neovascularization, Pathologic diagnosis
Prognosis
Skin Neoplasms blood supply
Skin Neoplasms diagnosis
Skin Neoplasms mortality
Survival Rate
Dog Diseases diagnosis
Melanoma veterinary
Mouth Neoplasms veterinary
Neovascularization, Pathologic veterinary
Skin Neoplasms veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1532-3129
- Volume :
- 147
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Journal of comparative pathology
- Publication Type :
- Academic Journal
- Accession number :
- 22520819
- Full Text :
- https://doi.org/10.1016/j.jcpa.2012.02.001