Risperidone-induced leukopenia: a case report and brief review of literature.

Authors :: Manfredi G
Solfanelli A
Dimitri G
Cuomo I
Sani G
Kotzalidis GD
Girardi P
Source :: General hospital psychiatry [Gen Hosp Psychiatry] 2013 Jan-Feb; Vol. 35 (1), pp. 102.e3-6. Date of Electronic Publication: 2012 Apr 18.
Publication Year :: 2013
Abstract: A Caucasian, male, young adult with recurrent agitated depression and suicidal ideation received lithium and oral olanzapine. His white blood cell count was normal at that time. Due to unsatisfactory response, he received 4 mg/day risperidone. While symptoms improved, leukopenia emerged, specifically directed towards neutrophils. Upon risperidone discontinuation, white blood cell count returned to reference values within 1 week. As symptom control was satisfactory, we attempted no risperidone rechallenge. Accurate blood testing must accompany atypical antipsychotic drug administration since blood dyscrasias are always possible with these drugs.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)