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[Complete genome sequence characteristics of human enterovirus 71 strain isolated in Yunnan, China].
- Source :
-
Bing du xue bao = Chinese journal of virology [Bing Du Xue Bao] 2012 Mar; Vol. 28 (2), pp. 108-13. - Publication Year :
- 2012
-
Abstract
- The complete nucleotide sequence of two human enterovirus 71 strains (KMM09 and KM186-09) isolated in Yunnan,China, were determined by RT-PCR and sequencing. As with other human enteroviruses, the genomes were 7 409 nucleotides (nts) in length and encoded 2 193 aa. Phylogenetic analysis based on VP1 regions revealed that the two isolates belonged to subgenotype C4a. In structural genomic regions, subgenotype C4 was most homologous to other strains of C genotype when compared to other genotypes. In non-structural genomic regions, subgenotype C4 was more homologous to CA16/G10 and other strains of B genotype than to other strains of C genotype. RDP3 and Blast analysis displayed evidence of recombination in non-structural genomic regions between subgenotype B3 and C4, C4 and CA16/G10. The full-length genome of the human enterovirus 71 strains provided an overview of the diversity of genetic characteristics of a circulatinghuman enterovirus 71.
Details
- Language :
- Chinese
- ISSN :
- 1000-8721
- Volume :
- 28
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Bing du xue bao = Chinese journal of virology
- Publication Type :
- Academic Journal
- Accession number :
- 22519170