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[Biology and relevance of stem cells in squamous head and neck cancer: latest insights and review of literature].
- Source :
-
Laryngo- rhino- otologie [Laryngorhinootologie] 2012 May; Vol. 91 (5), pp. 326-32; quiz 333-4. Date of Electronic Publication: 2012 Apr 19. - Publication Year :
- 2012
-
Abstract
- The initiation, growth, recurrence and metastasis of head and neck squamous cell carcinomas (HNSCC) and other cancers have recently been related to the presence of cancer stem cells (CSC). Cancer stem cells have some characteristics in common with tissue stem cells like unlimited self renewal and the expression of stem cell factors. CSC express specific markers that vary considerably depending on tumor type or tissue of origin--the discovery of an universal marker has not yet been made. Compared to the bulk tumor mass, CSC are less sensitive to chemo- and radiotherapy and also have a lower immunogenicity. Another concept that explains the seeding of metastases is the epithelial-mesenchymal transition of CSC. CSC-targeted therapies may change the prognosis of patients with HNSCC in the future. Recent knowledge on the role of CSC in HNSCC is reviewed, and known CSC markers as well as possible therapeutic targets are described.<br /> (© Georg Thieme Verlag KG Stuttgart · New York.)
- Subjects :
- Biomarkers, Tumor analysis
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell secondary
Carcinoma, Squamous Cell therapy
Cell Transformation, Neoplastic pathology
Disease Progression
Humans
Neoplasm Recurrence, Local pathology
Neoplasm Recurrence, Local physiopathology
Neoplasm Recurrence, Local therapy
Neoplasm Seeding
Neoplastic Stem Cells pathology
Otorhinolaryngologic Neoplasms pathology
Otorhinolaryngologic Neoplasms therapy
Carcinoma, Squamous Cell physiopathology
Neoplastic Stem Cells physiology
Otorhinolaryngologic Neoplasms physiopathology
Subjects
Details
- Language :
- German
- ISSN :
- 1438-8685
- Volume :
- 91
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Laryngo- rhino- otologie
- Publication Type :
- Academic Journal
- Accession number :
- 22517584
- Full Text :
- https://doi.org/10.1055/s-0032-1306364