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Stereoselective hydrofluorination of ynamides: a straightforward synthesis of novel α-fluoroenamides.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2012 May 25; Vol. 48 (42), pp. 5196-8. Date of Electronic Publication: 2012 Apr 18. - Publication Year :
- 2012
-
Abstract
- α-Fluoroenamides, potent rigid fluorinated bioisosters of ureas, have been synthesized by a highly regio- and stereo-selective hydrofluorination of ynamides in anhydrous HF. This reaction provides the first general entry to α-fluoroenamides and can easily be applied to a wide range of substrates.<br /> (This journal is © The Royal Society of Chemistry 2012)
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 48
- Issue :
- 42
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 22514037
- Full Text :
- https://doi.org/10.1039/c2cc31768k