A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity.

Authors :: Pejin B
Tommonaro G
Iodice C
Tesevic V
Vajs V
De Rosa S
Source :: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2013 Aug; Vol. 28 (4), pp. 876-8. Date of Electronic Publication: 2012 Apr 18.
Publication Year :: 2013
Abstract: The phytochemical investigation conducted on a foliose lichen, Lobaria pulmonaria(L.) Hoffm. (Lobariaceae), led to the isolation of a new depsidone in the form of its diacetate derivative which showed a moderate acetylcholinesterase inhibition activity (1 µg) in vitro. This is the first record of identified depsidone structure in searching for these inhibitors.

Subjects :: Cholinesterase Inhibitors chemistry
Cholinesterase Inhibitors isolation & purification
Depsides chemistry
Depsides isolation & purification
Enzyme Activation drug effects
Lactones chemistry
Lactones isolation & purification
Molecular Structure
Structure-Activity Relationship
Acetylcholinesterase metabolism
Ascomycota chemistry
Cholinesterase Inhibitors pharmacology
Depsides pharmacology
Lactones pharmacology

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