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Where rilpivirine meets with tenofovir, the start of a new anti-HIV drug combination era.
- Source :
-
Biochemical pharmacology [Biochem Pharmacol] 2012 Aug 01; Vol. 84 (3), pp. 241-8. Date of Electronic Publication: 2012 Apr 05. - Publication Year :
- 2012
-
Abstract
- The triple-drug once-daily combination pill containing tenofovir, emtricitabine and rilpivirine for HIV treatment was launched in 2011, both in the USA (Complera) and the E.U. (Eviplera). The active ingredients of Complera or Eviplera are the nucleotide reverse transcriptase inhibitor (NtRTI) tenofovir, the nucleoside reverse transcriptase inhibitor (NRTI) emtricitabine, and the non-nucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine. Rilpivirine originated from a collaborative research I had started with Dr. Paul Janssen in 1987, whereas tenofovir emanated from a collaborative research with Dr. Antonin Holý and Gilead Sciences. Exactly twenty-five years later rilpivirine and tenofovir joined each other, together with emtricitabine, in the same "combo" pill, representing a full treatment regimen for AIDS (HIV infection) based on a single once-daily pill.<br /> (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Subjects :
- Adenine administration & dosage
Animals
Deoxycytidine administration & dosage
Drug Combinations
Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
Emtricitabine
Emtricitabine, Rilpivirine, Tenofovir Drug Combination
HIV Infections epidemiology
Humans
Rilpivirine
Tenofovir
Adenine analogs & derivatives
Anti-HIV Agents administration & dosage
Deoxycytidine analogs & derivatives
Drug Therapy, Combination trends
HIV Infections drug therapy
HIV-1 drug effects
Nitriles administration & dosage
Organophosphonates administration & dosage
Oxazines administration & dosage
Pyrimidines administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2968
- Volume :
- 84
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biochemical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 22504027
- Full Text :
- https://doi.org/10.1016/j.bcp.2012.03.024