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ALDH marks leukemia stem cell.

Authors :
Fleischman AG
Source :
Blood [Blood] 2012 Apr 12; Vol. 119 (15), pp. 3376-7.
Publication Year :
2012

Abstract

In this issue of Blood,Gerber et al use aldehyde dehydrogenase (ALDH) activity to further subdivide the CD34(+)CD38(-) compartment in the bone marrow of acute myeloid leukemia (AML) patients. They identify a unique population with intermediate ALDH activity (ALDH(int)) that contains leukemia stem cells (LSCs). Moreover, persistence of this population after therapy is a marker of clinically significant minimal residual disease.

Subjects

Subjects :
Animals
Female
Humans
Male
Antigens, CD34 metabolism
Leukemia, Myeloid, Acute diagnosis
Leukemia, Myeloid, Acute pathology
Neoplastic Stem Cells pathology

Details

Language :
English
ISSN :
1528-0020
Volume :
119
Issue :
15
Database :
MEDLINE
Journal :
Blood
Publication Type :
Academic Journal
Accession number :
22500050
Full Text :
https://doi.org/10.1182/blood-2012-02-406751
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