Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder.

Authors :: Kurzwernhart A
Kandioller W
Bartel C
Bächler S
Trondl R
Mühlgassner G
Jakupec MA
Arion VB
Marko D
Keppler BK
Hartinger CG
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2012 May 18; Vol. 48 (40), pp. 4839-41. Date of Electronic Publication: 2012 Apr 12.
Publication Year :: 2012
Abstract: Ru(II)(arene)-flavonoids with high in vitro antitumour activity were synthesised. These compounds are capable of inhibiting human topoisomerase IIα and binding covalently to DNA.<br /> (This journal is © The Royal Society of Chemistry 2012)

Subjects :: Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Cell Line, Tumor
Cell Survival drug effects
Coordination Complexes chemistry
Coordination Complexes pharmacology
DNA-Binding Proteins antagonists & inhibitors
Flavonoids chemistry
Humans
Molecular Conformation
Protein Binding
Ruthenium chemistry
Antigens, Neoplasm metabolism
DNA metabolism
DNA Topoisomerases, Type II metabolism
DNA-Binding Proteins metabolism

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