Serum BAFF levels are related to angiogenesis and prognosis in patients with multiple myeloma.

Authors :: Fragioudaki M
Tsirakis G
Pappa CA
Aristeidou I
Tsioutis C
Alegakis A
Kyriakou DS
Stathopoulos EN
Alexandrakis MG
Source :: Leukemia research [Leuk Res] 2012 Aug; Vol. 36 (8), pp. 1004-8. Date of Electronic Publication: 2012 Apr 10.
Publication Year :: 2012
Abstract: B-cell activating factor (BAFF) is a B-cell growth factor. We measured its serum levels and correlated them with parameters of disease activity, as serum levels of tumor necrosis factor-α and lactate dehydrogenase, bone marrow microvascular density and proliferating cell nuclear antigen expression, in 50 myeloma patients, in 22 of them in plateau phase and in 20 controls. All of them were higher in patients and in advanced disease while reduced in plateau phase. BAFF correlated with all the above markers. Higher BAFF levels predicted a shorter survival, suggesting an important prognostic marker and a possible therapeutic target in myeloma.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)

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