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Annexin A4 is a possible biomarker for cisplatin susceptibility of malignant mesothelioma cells.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2012 Apr 27; Vol. 421 (1), pp. 140-4. Date of Electronic Publication: 2012 Apr 04. - Publication Year :
- 2012
-
Abstract
- Mesothelioma is a highly malignant tumor with a poor prognosis and limited treatment options. Although cisplatin (CDDP) is an effective anticancer drug, its response rate is only 20%. Therefore, discovery of biomarkers is desirable to distinguish the CDDP-susceptible versus resistant cases. To this end, differential proteome analysis was performed to distinguish between mesothelioma cells of different CDDP susceptibilities, and this revealed that expression of annexin A4 (ANXA4) protein was higher in CDDP-resistant cells than in CDDP-susceptible cells. Furthermore, ANXA4 expression levels were higher in human clinical malignant mesothelioma tissues than in benign mesothelioma and normal mesothelial tissues. Finally, increased susceptibility was observed following gene knockdown of ANXA4 in mesothelioma cells, whereas the opposite effect was observed following transfection of an ANXA4 plasmid. These results suggest that ANXA4 has a regulatory function related to the cisplatin susceptibility of mesothelioma cells and that it could be a biomarker for CDDP susceptibility in pathological diagnoses.<br /> (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Subjects :
- Annexin A4 genetics
Cell Line, Tumor
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
Humans
Neoplasms, Mesothelial genetics
Annexin A4 metabolism
Antineoplastic Agents pharmacology
Biomarkers, Pharmacological metabolism
Cisplatin pharmacology
Drug Resistance, Neoplasm
Neoplasms, Mesothelial metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 421
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 22497892
- Full Text :
- https://doi.org/10.1016/j.bbrc.2012.03.144