Back to Search
Start Over
Comparative anatomy of marmoset and mouse cortex from genomic expression.
- Source :
-
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2012 Apr 11; Vol. 32 (15), pp. 5039-53. - Publication Year :
- 2012
-
Abstract
- Advances in mouse neural circuit genetics, brain atlases, and behavioral assays provide a powerful system for modeling the genetic basis of cognition and psychiatric disease. However, a critical limitation of this approach is how to achieve concordance of mouse neurobiology with the ultimate goal of understanding the human brain. Previously, the common marmoset has shown promise as a genetic model system toward the linking of mouse and human studies. However, the advent of marmoset transgenic approaches will require an understanding of developmental principles in marmoset compared to mouse. In this study, we used gene expression analysis in marmoset brain to pose a series of fundamental questions on cortical development and evolution for direct comparison to existing mouse brain atlas expression data. Most genes showed reliable conservation of expression between marmoset and mouse. However, certain markers had strikingly divergent expression patterns. The lateral geniculate nucleus and pulvinar in the thalamus showed diversification of genetic organization between marmoset and mouse, suggesting they share some similarity. In contrast, gene expression patterns in early visual cortical areas showed marmoset-specific expression. In prefrontal cortex, some markers labeled architectonic areas and layers distinct between mouse and marmoset. Core hippocampus was conserved, while afferent areas showed divergence. Together, these results indicate that existing cortical areas are genetically conserved between marmoset and mouse, while differences in areal parcellation, afferent diversification, and layer complexity are associated with specific genes. Collectively, we propose that gene expression patterns in marmoset brain reveal important clues to the principles underlying the molecular evolution of cortical and cognitive expansion.
- Subjects :
- Animals
Brain Chemistry genetics
Callithrix
Cerebral Cortex metabolism
Female
Genetic Markers
Geniculate Bodies metabolism
Hippocampus metabolism
Image Processing, Computer-Assisted
In Situ Hybridization
Male
Mice
Polymerase Chain Reaction
Prefrontal Cortex metabolism
Pulvinar metabolism
Species Specificity
Thalamic Nuclei anatomy & histology
Thalamic Nuclei metabolism
Visual Cortex metabolism
Brain Mapping methods
Cerebral Cortex anatomy & histology
Gene Expression physiology
Genomics methods
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2401
- Volume :
- 32
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 22496550
- Full Text :
- https://doi.org/10.1523/JNEUROSCI.4788-11.2012