Back to Search
Start Over
Dehydrative C-H alkylation and alkenylation of phenols with alcohols: expedient synthesis for substituted phenols and benzofurans.
- Source :
-
Journal of the American Chemical Society [J Am Chem Soc] 2012 May 02; Vol. 134 (17), pp. 7325-8. Date of Electronic Publication: 2012 Apr 17. - Publication Year :
- 2012
-
Abstract
- A well-defined cationic Ru-H complex catalyzes the dehydrative C-H alkylation reaction of phenols with alcohols to form ortho-substituted phenol products. Benzofuran derivatives are efficiently synthesized from the dehydrative C-H alkenylation and annulation reaction of phenols with 1,2-diols. The catalytic C-H coupling method employs cheaply available phenols and alcohols, exhibits a broad substrate scope, tolerates carbonyl and amine functional groups, and liberates water as the only byproduct.<br /> (© 2012 American Chemical Society)
Details
- Language :
- English
- ISSN :
- 1520-5126
- Volume :
- 134
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 22494241
- Full Text :
- https://doi.org/10.1021/ja302710v