Back to Search
Start Over
Controlled human blood stage malaria infection: current status and potential applications.
- Source :
-
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2012 Apr; Vol. 86 (4), pp. 561-5. - Publication Year :
- 2012
-
Abstract
- Controlled human malaria infection by blood stage parasite (BSP) inoculation is an alternative to the well-established model of infection with Plasmodium falciparum sporozoites delivered by mosquito bites. The BSP model has been utilized less frequently, but its use is increasing. Advantages of BSP challenge include greater ease of administration, better standardization of the infecting dose per volunteer, and good inter-study reproducibility of in vivo parasite dynamics. Recently, a surprising reduction in clinical symptoms at microscopic patency in the BSP model has been identified, which has an undefined and intriguing pathophysiologic basis, but may make this approach more acceptable to volunteers. We summarize clinical, parasitologic, and immunologic data from all BSP challenges to date, explore differences between the BSP and sporozoite models, and propose future applications for BSP challenge.
- Subjects :
- Animals
Anopheles parasitology
Anopheles pathogenicity
Humans
Insect Bites and Stings parasitology
Malaria Vaccines immunology
Malaria, Falciparum parasitology
Plasmodium falciparum growth & development
Plasmodium falciparum pathogenicity
Sporozoites immunology
Malaria, Falciparum blood
Malaria, Falciparum pathology
Malaria, Falciparum prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1476-1645
- Volume :
- 86
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The American journal of tropical medicine and hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 22492136
- Full Text :
- https://doi.org/10.4269/ajtmh.2012.11-0504