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Vaccinia recombinant virus expressing the rabies virus glycoprotein: safety and efficacy trials in Canadian wildlife.
- Source :
-
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire [Can J Vet Res] 1990 Oct; Vol. 54 (4), pp. 504-7. - Publication Year :
- 1990
-
Abstract
- Twenty-six meadow voles (Microtus pennsylvanicus), ten woodchucks (Marmota monax), thirteen grey squirrels (Sciurus carolinensis), thirteen ring-billed gulls (Larus delawarensis), six red-tailed hawks (Buteo jamaicensis) and eight great horned owls (Bubo virginianus) received vaccinia virus recombinant expressing the rabies virus glycoprotein (V-RG) by direct instillation into the oral cavity. Each of ten coyotes (Canis latrans) received the virus in two vaccine-laden baits. Several voles and most of the gulls died from diseases unrelated to vaccination during the observation period, but all other animals remained healthy and survived. These deaths from causes other than vaccination and the absence of any lesions suggestive of vaccinia infection indicate that it is unlikely that any animal suffered or died as a result of V-RG administration. In addition several animals showed an unexpected high level of rabies neutralizing antibodies.
- Subjects :
- Administration, Oral
Animals
Arvicolinae
Birds
Carnivora
Glycoproteins immunology
Marmota
Ontario
Rabies virus immunology
Sciuridae
Vaccines, Synthetic administration & dosage
Vaccinia virus
Viral Proteins immunology
Animals, Wild
Rabies prevention & control
Rabies Vaccines administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0830-9000
- Volume :
- 54
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Canadian journal of veterinary research = Revue canadienne de recherche veterinaire
- Publication Type :
- Academic Journal
- Accession number :
- 2249183