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Colonization by Pneumocystis jirovecii and its role in disease.
- Source :
-
Clinical microbiology reviews [Clin Microbiol Rev] 2012 Apr; Vol. 25 (2), pp. 297-317. - Publication Year :
- 2012
-
Abstract
- Although the incidence of Pneumocystis pneumonia (PCP) has decreased since the introduction of combination antiretroviral therapy, it remains an important cause of disease in both HIV-infected and non-HIV-infected immunosuppressed populations. The epidemiology of PCP has shifted over the course of the HIV epidemic both from changes in HIV and PCP treatment and prevention and from changes in critical care medicine. Although less common in non-HIV-infected immunosuppressed patients, PCP is now more frequently seen due to the increasing numbers of organ transplants and development of novel immunotherapies. New diagnostic and treatment modalities are under investigation. The immune response is critical in preventing this disease but also results in lung damage, and future work may offer potential areas for vaccine development or immunomodulatory therapy. Colonization with Pneumocystis is an area of increasing clinical and research interest and may be important in development of lung diseases such as chronic obstructive pulmonary disease. In this review, we discuss current clinical and research topics in the study of Pneumocystis and highlight areas for future research.
- Subjects :
- HIV Infections complications
Humans
Immunocompromised Host
Pneumocystis carinii immunology
Pneumonia, Pneumocystis transmission
Carrier State microbiology
Pneumocystis carinii growth & development
Pneumocystis carinii pathogenicity
Pneumonia, Pneumocystis epidemiology
Pneumonia, Pneumocystis microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6618
- Volume :
- 25
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical microbiology reviews
- Publication Type :
- Academic Journal
- Accession number :
- 22491773
- Full Text :
- https://doi.org/10.1128/CMR.00013-12