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Effect of donor and recipient factors on corneal graft rejection.
- Source :
-
Cornea [Cornea] 2012 Oct; Vol. 31 (10), pp. 1141-7. - Publication Year :
- 2012
-
Abstract
- Purpose: To assess the relationship between donor and recipient factors and corneal allograft rejection in eyes that underwent penetrating keratoplasty in the Cornea Donor Study.<br />Methods: Overall, 1090 subjects undergoing corneal transplantation for a moderate risk condition (principally Fuchs dystrophy or pseudophakic corneal edema) were followed for up to 5 years. Associations of baseline recipient and donor factors with the occurrence of a probable or definite rejection event were assessed in univariate and multivariate proportional hazards models.<br />Results: Eyes with pseudophakic or aphakic corneal edema (n = 369) were more likely to experience a rejection event than eyes with Fuchs dystrophy (n = 676) [34% ± 6% vs. 22% ± 4%; hazard ratio = 1.56; 95% confidence interval (CI), 1.21-2.03]. Among eyes with Fuchs dystrophy, a higher probability of a rejection event was observed in phakic posttransplant eyes compared with those that underwent cataract extraction with or without intraocular lens implantation during penetrating keratoplasty (29% vs. 19%; hazard ratio = 0.54; 95% CI, 0.36-0.82). Female recipients had a higher probability of a rejection event than male recipients (29% vs. 21%; hazard ratio = 1.42; 95% CI, 1.08-1.87) after controlling for the effect of preoperative diagnosis and lens status. Donor age and donor recipient ABO compatibility were not associated with rejection.<br />Conclusions: There was a substantially higher graft rejection rate in eyes with pseudophakic or aphakic corneal edema compared to that in eyes with Fuchs dystrophy. Female recipients were more likely to have a rejection event than male recipients. Graft rejection was not associated with donor age.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Aphakia, Postcataract complications
Child
Corneal Edema etiology
Corneal Edema surgery
Female
Fuchs' Endothelial Dystrophy etiology
Fuchs' Endothelial Dystrophy surgery
Graft Rejection diagnosis
Humans
Male
Middle Aged
Proportional Hazards Models
Pseudophakia complications
Risk Factors
Transplantation, Homologous
Young Adult
Graft Rejection etiology
Keratoplasty, Penetrating
Tissue Donors
Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 1536-4798
- Volume :
- 31
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Cornea
- Publication Type :
- Academic Journal
- Accession number :
- 22488114
- Full Text :
- https://doi.org/10.1097/ICO.0b013e31823f77f5