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Opioid analgesics in experimental sepsis: effects on physiological, biochemical, and haemodynamic parameters.
- Source :
-
Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2013 Aug; Vol. 27 (4), pp. 347-53. Date of Electronic Publication: 2012 Apr 05. - Publication Year :
- 2013
-
Abstract
- Cecal ligation and puncture (CLP) is the sepsis model that more closely resembles the human pathology, but it is likely to cause suffering to experimental animals. However, it is not clear whether the use of analgesia may affect some parameters evaluated in experimental sepsis research. Therefore, we investigated the effects of fentanyl and tramadol in experimental sepsis in the rat. The following parameters were evaluated: body temperature, body weight, water and food ingestion, mortality, analgesia, blood leukocytes, mean arterial blood pressure, vascular reactivity to phenylephrine, lung myeloperoxidase activity, and plasma levels of IL1-β, glutamic-oxaloacetic, glutamic-pyruvic, lactate, creatinine and urea. While producing significant analgesia, the opioids modify minimally the parameters, with the exception of sepsis-induced hypotension and mortality. Although fentanyl and tramadol can minimize pain and the general suffering of animals submitted to CLP surgery, their effects on cardiovascular parameters as well as in the mortality indicate that their use in experimental sepsis must be done with caution and with all the proper control groups.<br /> (© 2012 The Authors Fundamental and Clinical Pharmacology © 2012 Société Française de Pharmacologie et de Thérapeutique. Published by John Wiley & Sons Ltd.)
- Subjects :
- Animals
Cardiovascular System drug effects
Cardiovascular System metabolism
Cardiovascular System physiopathology
Disease Models, Animal
Eating drug effects
Eating physiology
Female
Fentanyl pharmacology
Hemodynamics physiology
Rats
Sepsis mortality
Tramadol pharmacology
Water metabolism
Analgesics, Opioid pharmacology
Biochemical Phenomena drug effects
Body Temperature drug effects
Body Weight drug effects
Hemodynamics drug effects
Sepsis drug therapy
Sepsis physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1472-8206
- Volume :
- 27
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Fundamental & clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 22486445
- Full Text :
- https://doi.org/10.1111/j.1472-8206.2012.01041.x