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Activated leukocyte cell adhesion molecule (CD166)--its prognostic power for colorectal cancer patients.
- Source :
-
The Journal of surgical research [J Surg Res] 2012 Sep; Vol. 177 (1), pp. e15-20. Date of Electronic Publication: 2012 Mar 30. - Publication Year :
- 2012
-
Abstract
- Background: The activated leukocyte cell adhesion molecule (ALCAM, CD166) has been reported to be involved in tumorigenesis of colorectal cancer (CRC) and to function as a cancer stem cell marker. Controversial data exist regarding the prognostic power of ALCAM expression in CRC. Here, we evaluate the expression of ALCAM in a cohort of CRC patients and its usage as a prognostic marker for survival.<br />Materials and Methods: Tissue specimens from 299 patients with CRC treated between 1993 and 2006 were analyzed via ALCAM immunohistochemistry (clone MOG/07) using a tissue microarray. Results were correlated with clinical, histopathological, and patient survival data (Chi-square test, Kaplan-Meier analysis, and log-rank test, respectively). Multivariate analysis also was performed (Cox regression).<br />Results: ALCAM is expressed in most primary (76%) and secondary (62%) CRC lesions (P = 0.014). Immunohistochemistry revealed an inverse association with tumor grading (P = 0.002) but not with any other clinical or histopathological data. Kaplan-Meier survival analysis revealed a significant overall survival benefit in the group of ALCAM-positive patients (P = 0.019). Multivariate analysis showed that ALCAM is an independent positive prognostic marker for overall survival (P = 0.023).<br />Conclusions: ALCAM expression is a positive prognostic marker for overall survival of CRC patients, and its detection might help to optimize the existing prognostic staging system. Elevated expression in higher differentiated tumors might indicate a potential role in the early steps of tumorigenesis, and its loss might be associated with reduced cellular adhesion, resulting in a higher metastatic potential of the tumor. Further studies must be conducted investigating these hypotheses.<br /> (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Colon pathology
Colorectal Neoplasms mortality
Colorectal Neoplasms pathology
Female
Humans
Kaplan-Meier Estimate
Liver pathology
Liver Neoplasms metabolism
Liver Neoplasms pathology
Liver Neoplasms secondary
Lymph Nodes metabolism
Lymph Nodes pathology
Male
Middle Aged
Multivariate Analysis
Neoplasm Metastasis
Prognosis
Young Adult
Antigens, CD metabolism
Biomarkers, Tumor metabolism
Cell Adhesion Molecules, Neuronal metabolism
Colorectal Neoplasms metabolism
Fetal Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1095-8673
- Volume :
- 177
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of surgical research
- Publication Type :
- Academic Journal
- Accession number :
- 22482754
- Full Text :
- https://doi.org/10.1016/j.jss.2012.02.013