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Effect of 5-iodo-5'-amino-2',5'-dideoxyuridine on varicella-zoster virus in vitro.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1979 Jul; Vol. 16 (1), pp. 92-7. - Publication Year :
- 1979
-
Abstract
- The antiviral effect of the nucleoside analog 5-iodo-5'-amino-2',5'-dideoxyuridine (AIU) was tested with three isolates of varicella-zoster virus (VZV). AIU concentrations of 10 to 800 muM (3.5 to 288 mug/ml) reduced the number of plaques produced by VZV-infected cells and cell-free VZV from approximately 30 to 95%. Smaller plaque size was also observed in the presence of AIU. AIU was less effective than arabinofuranosylthymine in reducing VZV-induced plaques since as little as 5 mug of arabinofuranosylthymine per ml completely blocked plaque formation by cell-free VZV. Toxicity assays with human diploid embryo fibroblast cells were also carried out. Drug concentrations as high as 800 muM were not toxic to human diploid embryo fibroblast cells as determined by radiolabeling of cell deoxyribonucleic acid, ribonucleic acid, and protein.
- Subjects :
- Arabinonucleosides pharmacology
Cells, Cultured
DNA, Viral biosynthesis
Diploidy
Embryo, Mammalian
Fibroblasts drug effects
Herpesvirus 3, Human growth & development
Humans
Idoxuridine pharmacology
RNA, Viral biosynthesis
Thymidine pharmacology
Viral Plaque Assay
Viral Proteins biosynthesis
Virus Replication drug effects
Herpesvirus 3, Human drug effects
Idoxuridine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0066-4804
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 224809
- Full Text :
- https://doi.org/10.1128/AAC.16.1.92