Current Pharmacological Management in Juvenile Huntington's Disease.

Authors :: Robertson L
Santini H
O'Donovan KL
Squitieri F
Barker RA
Rakowicz M
Landwehrmeyer GB
Quarrell O
Source :: PLoS currents [PLoS Curr] 2012 Feb 15; Vol. 4, pp. RRN1304. Date of Electronic Publication: 2012 Feb 15.
Publication Year :: 2012
Abstract: Background: The clinical presentation of Juvenile Huntington's Disease (JHD) can be very different from adult-onset HD with little evidence to guide symptomatic management.<br />Aim: To survey the current use of pharmacological treatments for JHD.<br />Methods: Patients were identified through the HD Association, Hospital Doctors and the European Huntington's Disease Network REGISTRY study.<br />Results: The most commonly prescribed agents were anti-psychotics (24/45), anti-depressants (17/45) and anti-parkinsonian medications (15/45). 5 patients were taking more than 8 medications.<br />Conclusions: The most commonly prescribed group of medication was the anti-psychotic. Many patients were on multiple therapies, highlighting the need to rationalise medications.